DcR1 functions as a TRAIL-neutralizing decoy-receptor. Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. lentivirus, AAV, adenovirus), VectorBuilder Virus packaging for TNFSF8 (ie. Belongs to the tumor necrosis factor family. Alternatively spliced transcript variants encoding distinct isoforms have been identified. RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin (OPG), a ligand for the receptor RANK and controls cell proliferation by modifying protein levels of Id4, Id2 and cyclin D1. 2016 Jul 3;2016. pii: baw100. Two alternatively spliced transcript variants have been found. Instead, much of the content from Genetics Home Reference has been transferred to MedlinePlus, the NLM’s flagship website for health information for patients, families, and the general public. Click the + buttons to view associations for TNFSF13B from the datasets below. These mutations are displayed at the amino acid level across the full length of the gene by default. The information on this page was automatically extracted from online scientific databases. Rouillard AD, Gundersen GW, Fernandez NF, Wang Z, Monteiro CD, McDermott MG, Ma'ayan A. BD2K-LINCS Data Coordination and Integration Center, tumor necrosis factor (ligand) superfamily, member 9, The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. knockout, knockin, CRISPRa, CRISPRi), VectorBuilder Virus packaging for TNFSF8 CRISPR vectors (ie. TNFSF: Tumor necrosis factor (ligand) superfamily 3 InterPro protein domains: IPR006052 TNF_dom IPR008983 Tumour_necrosis_fac-like_dom ... Common genetic variants in candidate genes and risk of familial lymphoid malignancies. TRAIL binds to the death receptors DR4 (TRAIL-RI) and DR5 (TRAIL-RII). cellular components containing TNFSF9 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. small molecule perturbations changing expression of TNFSF9 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP, UniProtKB/Swiss-Prot and
The harmonizome: a collection of processed datasets gathered to serve and mine knowledge In cells expressing DcR2, TRAIL binding therefore activates NFkappaB, leading to transcription of genes known to antagonize the death signaling pathway and/or to promote inflammation. [provided by RefSeq, Nov 2011]. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. [9], TRAIL has also been designated CD253 (cluster of differentiation 253) and TNFSF10 (tumor necrosis factor (ligand) superfamily, member 10).[7]. Get the latest research from NIH: https://www.nih.gov/coronavirus. It causes apoptosis primarily in tumor cells,[7] by binding to certain death receptors. transcription factors binding the promoter of TNFSF13B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. Protein differential expression in normal tissues ,
cell lines with high or low expression of TNFSF9 gene relative to other cell lines from the Klijn et al., Nat. tissues co-occuring with TNFSF9 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. phenotypes of transgenic mice caused by TNFSF13B gene mutations from the MPO Gene-Phenotype Associations dataset. tissues with high or low expression of TNFSF13B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. Ensembl, locations according to GeneLoc
Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. tissue samples with high or low expression of TNFSF9 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. TNFSF9 has 4,286 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 72 datasets. transcription factor perturbations changing expression of TNFSF9 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. Feb 2016, "Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily", "Luminescent Iridium Complex-Peptide Hybrids (IPHs) for Therapeutics of Cancer: Design and Synthesis of IPHs for Detection of Cancer Cells and Induction of Their Necrosis-Type Cell Death", "On the TRAIL to successful cancer therapy?
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